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The latter studies have been performed using cohorts from Denmark [ 10 ], Japan [ 11 ] and Poland [ 12 ], as well as the MMR vaccine and pervasive developmental disorder in Canada [ 13 ]. Although low birthweight LBW has been shown to be associated with an increased risk of autism [ 28 ], insufficient information existed within the study population to assess the effect of LBW on autism incidence or any interaction between LBW and MMR timing. Study population As reported by Destefano et al. Arch Intern Med , This article is published under license to BioMed Central Ltd. Med Sci Monit , PI Vitamin D has also been implicated in many important physiological processing including modulation of activated T and B lymphocyte function [ 21 , 22 ] and prevention of inflammatory bowel disease [ 23 ].

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